Organoid research in digestive system tumors (Review)
نویسندگان
چکیده
منابع مشابه
Organoid Models and Applications in Biomedical Research.
Recent technical advances in the stem cell field have enabled the in vitro generation of complex structures resembling whole organs termed organoids. Most of these approaches employ three-dimensional (3D) culture systems that allow stem cell-derived or tissue progenitor cells to self-organize into 3D structures. These systems evolved, methodologically and conceptually, from classical reaggregat...
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Local-regional and peritoneal metastases still develop despite improvements in surgical techniques. Intraperitoneal chemotherapy has been proved to be effective in reducing the rate of local-regional and peritoneal metastases in many malignancies. There is adequate evidence that intraperitoneal perioperative chemotherapy after aggressive resection of locally advanced tumors of the digestive sys...
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Several human and murine colon cancer cell lines have been established, physiologic integrity of colon tumors such as multiple cell layers, basal-apical polarity, ability to differentiate, and anoikis are not maintained in colon cancer derived cell lines. The present study demonstrates a method for culturing primary mouse colon tumor organoids adapted from Sato T et al. (1), which retains impor...
متن کاملClocking the Pace of Organoid Research
rganoids are 3-dimensional structures that reflect Osome of the complex features of a native tissue, making them “organ like.” Organoids have seen a rapid growth in popularity and are becoming a mainstay in gastrointestinal research, owing in part to the ability of organoids to recapitulate some physiological functions of the tissue from which they are derived. For example, intestinal organoids...
متن کاملEthical issues in human organoid and gastruloid research.
Research involving human organoids and gastruloids involves ethical issues associated with their derivation as well as their current and future uses. These include unique issues related to the extent of maturation that can be achieved in vitro or through chimeric research, as well as fundamental ethical considerations such as those concerning the provenance of human biomaterials and the use of ...
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ژورنال
عنوان ژورنال: Oncology Letters
سال: 2021
ISSN: 1792-1074,1792-1082
DOI: 10.3892/ol.2021.12569